Skype has updated to version 1.0.2 on the App Store (iTunes link). The update mostly includes basic bug fixes but also includes a very interesting warning. iClarified reader (and jailbreaker) Francois noticed this new little warning when he launched his updated copy of Skype.
"This version of Skype is only supported on unmodified iPhone OS 2.2"
While the warning appears to be threatening he was able to continue to use the app normally. The warning is most likely intended to notice jailbreakers that Skype may have incompatibilities with jailbroken apps that do not use MobileSubstrate (you can read all about it in Cydia) and that Skype does not support issues that may arise because of that.